Calicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genome

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dc.contributor.affiliation000000041762408X
dc.contributor.affiliationDepartment of Structure of Macromolecules, CSIC - Centro Nacional de Biotecnologia (CNB), Madrid, Madrid, Spain; IMDEA Nanociencia, Madrid, Madrid, Spain; CSIC - Centro de Investigación en Sanidad Animal (CISA-INIA), Valdeolmos, Madrid, Spain; Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom; Consejo Superior de Investigaciones Científicas, Madrid, Madrid, Spainen
dc.contributor.authorNovoa, G.
dc.contributor.authorMata, C.P.
dc.contributor.authorMertens, Johann
dc.contributor.authorZamora-Ceballos, M.
dc.contributor.authorMartínez-Romero, J.M.
dc.contributor.authorFontana, J.
dc.contributor.authorCarrascosa, J.L.
dc.contributor.authorBárcena, J.
dc.contributor.authorCastón, J.R.
dc.date.accessioned2026-02-17T15:01:49Z
dc.date.available2026-02-17T15:01:49Z
dc.date.issued2025
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1371/journal.ppat.1013364
dc.identifier.urihttps://hdl.handle.net/20.500.12614/4192
dc.issue.numbere1013364
dc.journal.titlePLOS Pathogensen
dc.language.isoenen
dc.relation.projectIDTEMPFunding text 1: This work was supported by grants from the Spanish Ministry of Science and Innovation (PID2020\u2011113287RB\u2011I00 and PID2023\u2011146143NB\u2011I00) to J.R.C., PID2022\u2011140925OB\u2011I00 to J.B., and PID2023\u2011 149259NB\u2011I00 to J.F. M.Z\u2011C held a PhD fellow\u2011 ship from the Spanish Ministry of Science and Innovation (BES\u20112017\u2011081188). The CNB\u2011CSIC was further supported by an institutional grant from the Severo Ochoa Program for Centers of Excellence in R&D (CEX2023\u2011001386\u2011S/ AEI/10.13039/501100011033). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Roc\u00EDo Arranz and Javier Chich\u00F3n of the CNB-CSIC Cryo-EM facility (Madrid) for help with cryo-EM data acquisition, Elisa Torres and Carolina Cabezas at CISA-INIA/CSIC lab for their technical assistance, and Catherine Mark for editorial assistance. We acknowledge the UK national electron Bio-Imaging Centre (eBIC) and the Astbury Biostructure Laboratory for access and support of the cryo-EM facilities.; Funding text 2: Funding: This work was supported by grants from the Spanish Ministry of Science and Innovation (PID2020\u2011113287RB\u2011I00 and PID2023\u2011146143NB\u2011I00) to J.R.C., PID2022\u2011140925OB\u2011I00 to J.B., and PID2023\u2011 149259NB\u2011I00 to J.F. M.Z\u2011C held a PhD fellow\u2011 ship from the Spanish Ministry of Science and Innovation (BES\u20112017\u2011081188). The CNB\u2011CSIC was further supported by an institutional grant from the Severo Ochoa Program for Centers of Excellence in R&D (CEX2023\u2011001386\u2011S/ AEI/10.13039/501100011033). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.titleCalicivirus assembly and stability are mediated by the N-terminal domain of the capsid protein with the involvement of the viral genomeen
dc.typeresearch articleen
dc.type.hasVersionVoRen
dc.volume.number21

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