Ancestral Chaperonins Provide the First Structural Glimpse into Early Multimeric Protein Evolution

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dc.contributor.affiliation000000041762408X
dc.contributor.affiliationCSIC-INTA - Centro de Astrobiología (CAB), Torrejon de Ardoz, Madrid, Spain; Space Research and Astrobiology PhD Program, Universidad de Alcalá, Alcala de Henares, Madrid, Spain; CSIC - Centro Nacional de Biotecnologia (CNB), Madrid, Madrid, Spain; Unidad de Nanobiotecnología, IMDEA Nanociencia, Madrid, Madrid, Spainen
dc.contributor.authorSeverino, R.
dc.contributor.authorCuéllar, J.
dc.contributor.authorGutiérrez-Seijo, J.
dc.contributor.authorMaestro-López, M.
dc.contributor.authorSanchez-Pulido, L.
dc.contributor.authorSantiago, C.
dc.contributor.authorMoreno-Paz, M.
dc.contributor.authorValpuesta, J.M.
dc.contributor.authorParro, V.
dc.date.accessioned2026-02-17T15:01:49Z
dc.date.available2026-02-17T15:01:49Z
dc.date.issued2025
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1093/molbev/msaf314
dc.identifier.urihttps://hdl.handle.net/20.500.12614/4191
dc.issue.numbermsaf314
dc.journal.titleMolecular Biology and Evolutionen
dc.language.isoenen
dc.relation.projectIDTEMPFunding text 1: This research was supported by the Spain Ministry of Science and Innovation/Agencia Estatal de Investigaci\u00F3n (Spain) MCIN/AEI/10.13039/501100011033 and by \u201CERDF A way of making Europe\u201D through the grants No. PID2021-126746NB-I00 and RTI2018-094368-B-I00 to V.P., and PID2022-137175NB-I00 and the \u201CSevero Ochoa\u201D Program for Centers of Excellence in R&D (CEX2023-001386-S) to J.M.V. and J.C. The support of the grant CaixaResearch Health 2023 (HR23-00837) to J.M.V. is also acknowledged. R.S. was funded by a Ph.D. fellowship from INTA, by the fellowship \u201CFord-Apadrina la Ciencia,\u201D and by MCIU/AEI/10.13039/501100011033 and FSE+ through the grant PTA2022-022084-I. We thank Jos\u00E9 Manuel S\u00E1nchez Ruiz and Valeria Risso (Granada University, Spain), Miguel Arenas (University of Vigo, Spain), and Jos\u00E9 Berenguer (Autonomous University of Madrid, Spain), for critical insights and discussion. We arevery thankful to Diamond Light Source for access to a Titan Krios cryoelectron microscope (thanks to the proposal BI30374-8). We also acknowledge the technical support of the cryoEM CNB-CSIC facility.; Funding text 2: This research was supported by the Spain Ministry of Science and Innovation/Agencia Estatal de Investigaci\u00F3n (Spain) MCIN/AEI/10.13039/501100011033 and by \u201CERDF A way of making Europe\u201D through the grants No. PID2021-126746NB-I00 and RTI2018-094368-B-I00 to V.P., and PID2022-137175NB-I00 and the \u201CSevero Ochoa\u201D Program for Centers of Excellence in R&D (CEX2023-001386-S) to J.M.V. and J.C. The support of the grant CaixaResearch Health 2023 (HR23-00837) to J.M.V. is also acknowledged. R.S. was funded by a Ph.D. fellowship from INTA, by the fellowship \u201CFord-Apadrina la Ciencia,\u201D and by MCIU/AEI/10.13039/501100011033 and FSE+ through the grant PTA2022-022084-I.
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.titleAncestral Chaperonins Provide the First Structural Glimpse into Early Multimeric Protein Evolutionen
dc.typeresearch articleen
dc.type.hasVersionVoRen
dc.volume.number42

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