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Unambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X-Ray Imaging

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dc.contributor.affiliation"IMDEA Nanociencia, Faraday 9, Madrid, 28049, Spain"," MISTRAL beamline, ALBA Synchrotron Light Source, Cerdanyola del Vallès, Barcelona, 08290, Spain"," ID16A beamline, ESRF-The European Synchrotron, Grenoble, 38043, France"," Department of Structure of Macromolecules, Centro Nacional de Biotecnología/CSIC, Madrid, 28049, Spain"," Unidad Asociada de Nanobiotecnología CNB-CSIC-IMDEA, Madrid, 28049, Spain"," Current address: Department of Structure of Macromolecules, Centro Nacional de Biotecnología/CSIC, Madrid, 28049, Spain"en
dc.contributor.affiliation000000041762408X
dc.contributor.authorConesa J.J.
dc.contributor.authorCarrasco A.C.
dc.contributor.authorRodríguez-Fanjul V.
dc.contributor.authorYang Y.
dc.contributor.authorCarrascosa J.L.
dc.contributor.authorCloetens P.
dc.contributor.authorPereiro E.
dc.contributor.authorPizarro, Ana M.
dc.date.accessioned2020-12-04T15:19:28Z
dc.date.available2020-12-04T15:19:28Z
dc.date.issued2020
dc.identifier.doi10.1002/anie.201911510
dc.identifier.urihttp://hdl.handle.net/20.500.12614/1499
dc.journal.titleAngewandte Chemie - International Edition
dc.language.isoen
dc.page.initial1270
dc.relation.projectIDinfo:eu:eu-repo/grantAgreement/EC/FP7/631396/EU/Metallodrugs to Modulate Tumour Cell Machinery/MEMOTUMCELLMACH
dc.relation.projectIDTEMPWe thank C. Pati?o and B. Mart?n from Electron Microscopy Unit (CNB-CSIC) for preparing the ultrathin sections and for accommodating the TEM work. Dr. A. Arn?iz (IMDEA Nanociencia) is gratefully acknowledged for assistance with cell culture techniques. We acknowledge funding from the EC (FP7-PEOPLE-2013-CIG, No. 631396), from the MINECO of Spain (RYC-2012?11231, CTQ2014-60100-R, SEV-2016-0686, BFU 2014?54181-P, and CTQ2017-84932-P), and from the Comunidad Aut?noma de Madrid (S2013/MIT- 2850). Cryo-SXT experiments were performed at MISTRAL beamline at ALBA Synchrotron with the collaboration of ALBA staff (2017022061). Cryo-XRF experiments were performed at ID16A beamline at ESRF Synchrotron with the collaboration of ESRF staff, in the frame of proposals LS2767 (doi:10.15151/ESRF-ES-112668425) and IHLS3102 (doi:10.15151/ESRF-ES-103850884).
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleUnambiguous Intracellular Localization and Quantification of a Potent Iridium Anticancer Compound by Correlative 3D Cryo X-Ray Imaging
dc.typeresearch article
dc.volume.number59
dspace.entity.typePublication
relation.isAuthorOfPublicationf9db66bb-cc0a-4839-88fa-45ec5046a46a
relation.isAuthorOfPublication.latestForDiscoveryf9db66bb-cc0a-4839-88fa-45ec5046a46a

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