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A Complex Interplay of Anionic Phospholipid Binding Regulates 3'-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation

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dc.contributor.affiliation"Instituto Biofisika (CSIC, UPV/EHU), Leioa, 48490, Spain"," Protein Phosphorylation Laboratory, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, United Kingdom"," Institute of Chemistry & Biology of Membranes & Nanoobjects (UMR 5248 CBMN) CNRS – Université de Bordeaux - Bordeaux INP All. Geoffroy Saint-Hilaire, Pessac, 33600, France"," Cell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Instituto Biofisika (CSIC, UPV/EHU) & Research Centre for Experimental Marine Biology and Biotechnology (PiE), University of the Basque Country (UPV/EHU), Leioa, 48940, Spain"," Centre for Therapeutic Innovation (CTI-Bath)"," Cell Biophysics Laboratory Department of Pharmacy & Pharmacology University, Bath, Claverton Down, Bath, BA2 7AY, United Kingdom"," Centro Nacional de Biotecnología (CSIC), Darwin, 3, Madrid, E28049, Spain"," Unidad de Nanobiotecnología, CNB-CSIC-IMDEA Nanociencia Associated Unit, Madrid, 28049, Spain"en
dc.contributor.affiliation000000041762408X
dc.contributor.authorHeras-Martínez G.
dc.contributor.authorCalleja V.
dc.contributor.authorBailly R.
dc.contributor.authorDessolin J.
dc.contributor.authorLarijani B.
dc.contributor.authorRequejo, José
dc.date.accessioned2020-12-04T16:43:48Z
dc.date.available2020-12-04T16:43:48Z
dc.date.issued2019
dc.format.mimetypeapplication/pdfen
dc.identifier.doi10.1038/s41598-019-50742-8en
dc.identifier.urihttp://hdl.handle.net/20.500.12614/1700
dc.issue.number14527en
dc.journal.titleScientific Reportsen
dc.language.isoenen
dc.relation.projectIDTEMP"We are grateful to Peter J Parker, Len Stephens, Patrick Williamson and Vytas Bankaitis for scientific discussions and constructively reading the paper. Sonia López Fernandez for her help in the cloning and Unai López Sierra for technical assistance at the microscope. Supported by the Spanish Ministry of Economy grant to B.L. [BFU2015-65625-P] & Ministerio de Economía y Competitividad in Spain grant to J.R.-I., (MINECO FIS2009-07966)"," Royal Society grants to J.R.-I. and V.C. (IE120953). Basque Government PhD studentship to G.d.H."," Cancer Research UK Core Funding grants to B.L."," We also acknowledge the support of the Ikerbasque Foundation of Science to BL"," Centre National de la Recherche Sciéntifique (CNRS) and Ministere de l’Education Nationale et de l’Enseignement Supérieur et de la Recherche (MENSR) grants to J.D."
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleA Complex Interplay of Anionic Phospholipid Binding Regulates 3'-Phosphoinositide-Dependent-Kinase-1 Homodimer Activationen
dc.typeresearch articleen
dc.type.hasVersionVoRen
dc.volume.number9en
dspace.entity.typePublication

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