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Engineering protein assemblies with allosteric control via monomer fold-switching

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dc.contributor.affiliation"Centro Nacional de Biotecnología (CNB-CSIC), Darwin 3, Campus de Cantoblanco, Madrid, 28049, Spain"," Unidad Asociada de Nanobiotecnología IMDEA Nanociencia-CNB, Madrid, Spain"," Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid, 28040, Spain"," Departamento de Química Física, Facultad de Ciencias, Universidad de Granada, Campus Fuentenueva s/n, Granada, 18071, Spain"," Department of Bioengineering, University of California, Merced, CA 95343, United States"," NSF-CREST Center for Cellular and Biomolecular Machines, University of California, Merced, CA 95343, United States"," IMDEA Nanociencia, Programa de Nanobiosistemas, Faraday 9, Ciudad Universitaria Cantoblanco, Madrid, 28049, Spain"," School of Biochemistry, University of Bristol, Bristol, BS8 1TD, United Kingdom"en
dc.contributor.affiliation000000041762408X
dc.contributor.authorCampos L.A.
dc.contributor.authorSharma R.
dc.contributor.authorAlvira S.
dc.contributor.authorRuiz F.M.
dc.contributor.authorIbarra-Molero B.
dc.contributor.authorSadqi M.
dc.contributor.authorAlfonso C.
dc.contributor.authorRivas G.
dc.contributor.authorSanchez-Ruiz J.M.
dc.contributor.authorRomero Garrido A.
dc.contributor.authorValpuesta J.M.
dc.contributor.authorMuñoz V.
dc.date.accessioned2020-12-04T16:43:48Z
dc.date.available2020-12-04T16:43:48Z
dc.date.issued2019
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1038/s41467-019-13686-1
dc.identifier.urihttp://hdl.handle.net/20.500.12614/1699
dc.issue.number5703
dc.journal.titleNature Communications
dc.language.isoen
dc.relation.projectIDinfo:eu:eu-repo/grantAgreement/EC/FP7/323059/EU/Downhill Folding Protein Modules as Conformational Rheostats: Roles in Molecular Biology and Applications as Biosensors/MOLRHEOSTAT
dc.relation.projectIDTEMPThis work was supported by the European Research Council (grant ERC-2012-ADG-323059 to V.M.) and by the PRODESTECH network funded through the CONSOLIDER program from the Spanish Government (grant CSD2009-00088). L.A.C. acknowledges support from Ministry of Economy and Competitiveness through grants BIO2016-78768-P and RYC-2013-13197. V.M. acknowledges additional support from the W.M. Keck Foundation and from the CREST Center for Cellular and Biomomolecular Machines (grant NSF-CREST-1547848). J.M.V. acknowledges additional support from Ministry of Economy and Competitiveness through grant BFU2016-75984. F.M.R. and A.R. thank the staff from the ALBA synchrotron (Spain) for assistance with the XALOC beamline. Structural data are deposited in the Protein Data Bank with accession codes 6QIY (X-ray CI2 classical geometry) and 6QIZ (X-ray CI2 domain swapped) and EMD-4568 (cryo-EM CI2eng assembly).
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleEngineering protein assemblies with allosteric control via monomer fold-switching
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

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